Xicotil 20mg Tablet 10Pcs

Description:

IndicationsTenoxicam is used to treat the symptoms of the following musculoskeletal conditions that are painful, inflammatory, and degenerative:Rheumatoid arthritis is a type of arthritis that affects the joints.Ankylosing spondylitis is a type of arthritis that affects the spine.Tendinitis, bursitis, periarthritis of the shoulders (shoulder-hand syndrome) or hips, strains, and sprains are examples of extraarticular illnesses.Gout that is acute. PharmacologyTenoxicam inhibits human metalloproteinases (stromelysin and collagenase), which cause cartilage disintegration, in vitro. Tenoxicam’s therapeutic effectiveness in the treatment of painful inflammatory and degenerative musculoskeletal illnesses can be attributed to these pharmacological actions, at least in part. Tenoxicam had no mutagenic, carcinogenic, or toxic effects. In animals, there are teratogenic effects. In animal safety tests, renal and gastrointestinal symptoms, as well as an increased incidence of dystocia and delayed parturition, were identified, as with other prostaglandin inhibitors. Dosage and AdministrationStandard dosage: A daily dose of 20 mg should be administered at the same time of day for all indications except severe gout.In the case of acute gout episodes, the suggested dose is 40 mg once daily for two days, followed by 20 mg once daily for another five days.Tenoxicam has a therapeutic impact in the treatment of chronic illnesses that is noticeable early on, although the reaction gradually improves over time. Daily doses greater than 20 mg should be avoided in chronic illnesses since they increase the frequency and intensity of unpleasant responses without improving efficacy.A reduction to a daily oral dose of 10 mg may be explored for maintenance in patients who require long-term treatment.Special dosage instructions: The aforementioned dosage guidelines, in principle, also apply to older people and those with kidney or liver illness. Children and adolescent’s dose recommendations have yet to be defined due to a lack of clinical expertise. InteractionSalicylate, like other NSAIDs, displaces tenoxicam from protein-binding sites, increasing tenoxicam clearance and volume of distribution. Because of the increased risk of gastrointestinal side effects, concurrent therapy with salicylate or other NSAIDs should be avoided. Some NSAIDs and methotrexate co-administration has been linked to lower methotrexate renal tubular secretion, increased methotrexate plasma concentrations, and severe methotrexate toxicity. As a result, when Tenoxicam is used with methotrexate, vigilance should be exercised. In the tiny number of patients who received gold, penicillamine, or probenecid at the same time, no clinically significant interactions were discovered. Tenoxicam may reduce lithium clearance in the kidneys, so taking them together could result in higher plasma levels and toxicity. Lithium levels in the blood should be constantly checked. Tenoxicam should not be taken with K-sparing diuretics, as it should not be taken with NSAIDs in general. These two groups of drugs have been reported to interact, resulting in hyperkalemia and renal failure. Tenoxicam and furosemide have no clinically relevant interactions, however, Tenoxicam reduces the blood pressure-lowering impact of hydrochlorothiazide. Tenoxicam, like other NSAIDs, has been shown to reduce the antihypertensive effects of beta-blockers and ACE inhibitors. There have been no known interactions between NSAIDs and calcium channel blockers or centrally acting alpha agonists. When Tenoxicam was used with atenolol, there was no clinically significant interaction. During clinical studies, no interactions were reported in patients who were using digitalis medications at the same time. As a result, it appears that using Tenoxicam and Digoxin at the same time poses no significant danger. Concomitantly provided antacids, cimetidine, warfarin, and phenprocoumon at the prescribed dosages have shown no interaction. Tenoxicam had no influence on the clinical effect of oral antidiabetic medications (glibornuride, glibenclamide, tolbutamide). When patients are taking anticoagulants and oral antidiabetic medications at the same time, vigilant monitoring is necessary. Tenoxicam and low molecular weight heparin have been determined to have no clinically significant interactions. ContraindicationsTenoxicam should not be given to patients who are known to be hypersensitive to the drug; in whom salicylates or other non-steroidal anti-inflammatory drugs (NSAIDs) cause symptoms of asthma, rhinitis, or urticaria; or who are suffering from or have previously suffered from upper gastrointestinal tract disease such as gastritis, gastric, or duodenal ulcer. Side EffectsTenoxicam is well tolerated in the recommended dosage. Usually, the undesirable effects reported are mild and transient. These are gastrointestinal disorders: gastric, epigastric, and abdominal discomfort, dyspepsia, heartburn, nausea; nervous system disorders: dizziness, headache. Vertigo, sleep disturbance, palpitation, urticaria may occur in rarely. Pregnancy & LactationUse in Pregnancy: No data with tenoxicam exist in pregnant women.Use in Nursing mothers: Based on findings from single-dose administration, a very small amount of tenoxicam passes into breast milk. There is no evidence of adverse reactions in breast-fed infants of mothers taking Tenoxicam. Nevertheless, infants should be weaned or the medicine discontinued. Precautions & WarningsPatients with uncontrolled hypertension, congestive heart failure, established ischaemic heart disease, peripheral arterial disease, and/or cerebrovascular disease should only be treated with Tenoxicam after careful consideration. The use of tenoxicam with concomitant NSAIDs, including cyclooxygenase- 2 selective inhibitors should be avoided. NSAIDs should be given with care to patients with a history of IBD as their condition may be exacerbated. Caution is advised in patients receiving concomitant medications that could increase the risk of ulceration or bleeding, such as oral corticosteroids, anticoagulants, SSRI, or antiplatelet agents (e.g. Aspirin).Storage ConditionsStore below 30°C and keep away from light and moisture. Keep out of children’s reach.