Eromycin DS 500mg 6Pcs

Indications of Eromycin DS Tablet

A-Mycin is highly effective in the treatment of a wide variety of clinical infections, such as

• Upper respiratory tract infections: Tonsillitis, peritonsillar abscess, pharyngitis, laryngitis, sinusitis, and secondary infections in cold and influenza.
• Lower respiratory tract infections: Tracheitis, acute and chronic bronchitis. Mycoplasma pneumonia (lobar pneumonia, bronchopneumonia, primary atypical pneumonia), bronchiectasis.
• Skin and soft tissue infections: Boils and carbuncles, paronychia, abscesses, pustular acne, impetigo, cellulitis, furunculosis, erythrasma.
• General infections: Non-specific urethritis, syphilis (if the patient is allergic to penicillin).
• Gastrointestinal infections: Cholecystitis, Staphylococcal enterocolitis, infectious diarrhea, & cholera.
• Ear and oral infections: 0titis media and otitis externa, gingivitis, dental abscesses.
• Prophylaxis: Pre-operative and post-operative, trauma, burns, rheumatic fever.
• Other infections: Diphtheria, whooping cough.

Pharmacology of Eromycin DS Tablet

Erythromycin blocks the translocation process, which stops microsomal protein synthesis in sensitive organisms. These organisms have specific binding to the 50S subunit or the 70S ribosome, but no binding to the stable 80S mammalian ribosome. Erythromycin is effective against a wide range of Gram-positive and Gram-negative bacteria, as well as mycoplasmas and chlamydia. Because the base of erythromycin is destroyed by acid, it is given in the form of a stable ester. The presence of food reduces the rate of absorption of the base and esters. In the gut, the stearate is hydrolyzed, and the free erythromycin is absorbed. Peak serum concentrations of 0.9 to 1.4 or 0.4 to 1.8 mg/ml respectively are achieved in 1 to 4 hours after an oral dose of 500 mg of the base of stearate. The serum half-life ranges from 1.2 to 4 hours. The half-life in oliguria patients is roughly 5 hours.

Erythromycin is broadly dispersed throughout bodily tissue and fluids, with some retention in the liver and spleen. Erythromycin base has a 73 percent protein binding rate. When the meninges become inflamed, erythromycin enters the cerebrospinal fluid. It also passes through the placenta and is secreted in breast milk. The unmodified active ingredient is excreted in substantial amounts in the bile, and 5 to 15% of the erythromycin dose is eliminated in the urine.

Dosage and Administration of Eromycin DS Tablet

Adults: Usually 250 mg every 6 hours, or 500 mg every 12 hours. May increase up to 4 g/day, according to the severity of the infection.

Upper respiratory tract infections of mild to moderate severity: 

• 250 to 500 mg 4 times a day for 10 days

Lower respiratory infections of mild to moderate severity

• 250 to 500 mg 4 times a day for 10 days

Respiratory tract infections due to Mycoplasma pneumonia

• 500 mg 6 hours for 5 to 10 days treat severe infections for up to 3 weeks

Skin and soft tissue infections of mild to moderate severity

• 250 to 500 mg 4 times a day for 10 days

Urogenital infection during pregnancy caused by Chlamydia trachomatis

• 500 mg 4 times daily for 7 days or
• 250 mg 4 times daily for 14 days

Pelvic inflammatory diseases (PID), acute due to Neisseria gonorrhoeae

• 500 mg 4 times a day for 10 to 14 days

Non-gonococcal urethritis

• 500 mg 4 times daily for at least 7 days

Urethral, endocervical or rectal infections, uncomplicated

• 500 mg 4 times daily for 7 days or
• 250 mg 4 times daily for 14 days

Early syphilis (primary, secondary, or latent syphilis of < 1-year duration)

• 500 mg 4 times a day for 14 days

Bacterial endocarditis 

• 1 to 2 hours prior to procedures, then 500 mg 6 hours after an initial dose

Rheumatic fever

• 250 mg 2 times daily

Acne

• 500 mg twice daily for 3 months reduced to 250 mg twice for 3 months

Children:
The usual oral dose is 30-50 mg/kg body weight per day in divided doses. For more severe infections, the dose may be doubled.

Interaction of Eromycin DS Tablet

According to new research, using erythromycin in individuals who are taking a high dose of theophylline may result in a rise in serum theophylline levels and probable theophylline toxicity. In such circumstances, theophylline dosage should be lowered.

Contraindications

Erythromycin hypersensitivity is known.

Side effects of Eromycin DS Tablet

Gastrointestinal: Abdominal cramp & discomfort, nausea, vomiting & diarrhea. Hypersensitivity reaction may also be responsible for hepatotoxicity sometimes in patients receiving Erythromycin or its derivatives.

Pregnancy & Lactation

• Use in pregnancy: A-Mycin (Erythromycin) crosses the placenta. Fetal plasma concentrations are variously stated to the 5 to 20% of these in the mother.
• Use in lactation: It is readily excreted in breast milk.

Precautions & Warnings

Erythromycin should be used with care in patients with existing hepatic impairment. It has been suggested that Erythromycin should be used with care in patients with a history of arrhythmia.

Storage Conditions

Keep the temperature below 25?C and away from light and moisture. Keep out of children’s reach.