Description:
Indications of Atrogen 10 ml
Atropine is used to treat non-ulcer dyspepsia, irritable bowel syndrome, diverticular disease, bradycardia, organophosphorus poisoning, anesthesia premedication, muscarinic poisoning or overdosage, ophthalmic inflammatory eye diseases, and ocular refraction.
Pharmacology of Atrogen 10 ml
Atropine binds to muscarinic acetylcholine receptors and inhibits them, resulting in a variety of anticholinergic actions. Atropine is an anticholinergic drug that inhibits muscarinic receptors in peripheral tissues such as the heart, intestines, bronchial muscles, iris, and secretory glands. There may be some central stimulation. Atropine decreases heart block caused by vagal activity and eliminates bradycardia. The smooth muscles of the bronchi and intestines relax, and glandular secretions decrease. It also has a cycloplegic and mydriatic impact.
Dosage & Administration
Adult:
IV: Bradycardia: 500 mcg every 3-5 mins. Total: 3 mg.
IV/IM: Organophosphorus poisoning: 2 mg every 10-30 mins until muscarinic effects disappear or atropine toxicity appears.
IM/SC: Premedication in anesthesia: 300-600 mcg 30-60 mins before anesthesia.
IV/IM/SC: Poisoning or overdosage with a compound having muscarinic actions: 0.6-1 mg, repeat 2 hourly.
Ophthalmic: Inflammatory eye disorders: As 0.5-1% solution: 1-2 drops 4 times/day.
Ophthalmic: refraction: 1% solution 1 drop twice daily for 1-2 days before the procedure.
Oral: Non-ulcer dyspepsia, Irritable bowel syndrome, Diverticular disease: 0.6-1.2 mg as a single dose at bedtime.
Usual Pediatric Dose for Anesthesia:
7 to 16 pounds: 0.1 mg, IV, IM, or subcutaneously
17 to 24 pounds: 0.15 mg, IV, IM, or subcutaneously
24 to 40 pounds: 0.2 mg, IV, IM, or subcutaneously
40 to 65 pounds: 0.3 mg, IV, IM, or subcutaneously
65 to 90 pounds: 0.4 mg, IV, IM, or subcutaneously
Over 90 pounds: 0.4 to 0.6 mg, IV, IM, or subcutaneously
Interaction of Atrogen 10 ml
Quinidine, antidepressants, and certain antihistamines have additive anticholinergic effects.
Contraindications
Glaucoma, chronic obstructive pulmonary disease, sick sinus syndrome, thyrotoxicosis, heart failure, pyloric stenosis, and prostatic hypertrophy are some of the conditions that can affect men.
Side Effects of Atrogen 10 ml
Injection: Dry mouth, dysphagia, constipation, flushing and dry skin, tachycardia, palpitations, arrhythmias, mydriasis, photophobia, cycloplegia, increased intraocular pressure, tachycardia, palpitations, arrhythmias, mydriasis, photophobia, cycloplegia Tachycardia, hyperpyrexia, restlessness, disorientation, excitation, hallucinations, delirium, and circulatory failure may result with toxic dosages.
Eye drops or ointment: Systemic toxicity, especially in youngsters, can cause irritation, hyperemia, edema, and conjunctivitis with extended usage. Intraocular pressure has risen.
Pregnancy & Lactation
Pregnancy Classification C. Atropine has not been used in animal reproductive research. It’s also unclear whether atropine can damage a fetus or alter reproductive ability if administered to a pregnant woman. Atropine should only be administered to a pregnant woman if absolutely necessary.
Precautions & Warnings
Pregnancy; elderly; babies and children; reflux oesophagitis
Storage Conditions
Atropine should be kept at room temperature, between 20 and 25 degrees Celsius. Heat, moisture, and light should all be avoided when storing this item. Keep atropine out of children’s reach.
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