Description:
Indications
This Sterile Ophthalmic Solution is indicated for the treatment of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension who are insufficiently responsive to single therapy with prostaglandin analog or topical beta blocker.
Pharmacology
Travoprost and Timolol reduce intraocular pressure (IOP) by complementary mechanisms of action. Travoprost is a prostaglandin analogue that reduces IOP by increasing trabecular outflow & uveoscleral outflow. Timolol is a non-selective beta-adrenergic receptor blocker that does not have significant intrinsic sympathomimetic, direct myocardial depressant, or local anesthetic (membrane stabilizing) activity. It lowers IOP by decreasing the formation of aqueous humor in the ciliary epithelium.
Dosage & Administration
Instill one drop in the conjunctival sac of the affected eye(s) once daily at about the same time each day, preferably in the evening.
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Contraindications
Contraindicated in patients who are hypersensitive to Travoprost, Timolol or any of the components of this preparation.
Side Effects
No serious adverse reactions are reported. Most frequently reported side effects are ocular hyperemia.
Pregnancy & Lactation
Use in pregnancy: There are no adequate and well-controlled studies in pregnant women. It should not be used during pregnancy.
Use in lactation: Caution should be exercised when Travoprost + Timolol Maleate is administered to a nursing mother.
Precautions & Warnings
For ophthalmic use only. Patients should remove their contact lenses prior to instilling this preparation and should not insert their lenses until 15 minutes after instillation of the preparation.
Use in Special Populations
Use in children: Safety and effectiveness in pediatric patients have not been established.
Use in elderly patients: No overall differences in safety and effectiveness have been observed between elderly and other adult patients.
Storage Conditions
Store in a cool, dry place, away from heat and direct light. Keep out of the reach of children. Do not use it more than 4 weeks after opening the bottle
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