Azyth 250mg (10pcs Box)

Indications

Azyth is an antibiotic that is used in adults and children to treat bacterial infections of the respiratory tract, ear, nose, throat, lungs, skin, and eyes. It is also useful in the treatment of typhoid fever and some sexually transmitted diseases such as gonorrhea. Azyth is a broad-spectrum antibiotic that is effective against many gram-positive bacteria, some gram-negative bacteria, and other microorganisms. This medication is taken orally, preferably one hour before or two hours after eating. It should be taken on a regular basis at evenly spaced time intervals, as directed by your doctor.

Pharmacology

Azithromycin is acid-stable, so it can be taken orally without fear of being destroyed by stomach acids. It is quickly absorbed; its retention is more noticeable on a purge stomach. For verbal measurement shapes, the time to peak concentration in adults ranges from 2.1 to 3.2 hours. Because of its high concentration in phagocytes, azithromycin is efficiently transported to the site of the disease. Massive amounts of azithromycin are released during dynamic phagocytosis. Azithromycin concentrations in tissues can be more than 50 times higher than in plasma. This is frequently caused by particle catching and high lipid solubility. Because azithromycin is acid-stable, it can be taken orally without fear of being destroyed by gastric acids. It is quickly retained, and its retention is more noticeable on a purge stomach. For verbal measurement shapes, the time to crest concentration in adults ranges from 2.1 to 3.2 hours. Because of its high concentration in phagocytes, azithromycin is efficiently transported to the site of contamination. Azithromycin in high concentrations is released during dynamic phagocytosis. Azithromycin concentrations in tissues can be more than 50 times higher than in plasma. Usually because of particle catching and high lipid solubility.

• Microbiology: Azithromycin acts by binding to the 50S ribosomal subunit of susceptible microorganisms and, thus, interfering with microbial protein synthesis. Nucleic acid synthesis is not affected. Azithromycin has been shown to be active against most isolates of the following microorganisms, both in vitro and in clinical infections:
• Aerobic and facultative gram-positive microorganisms: Staphylococcus aureus, Streptococcus agalactiae, Streptococcus pneumonia, Streptococcus pyogenes
• Aerobic and facultative gram-negative microorganisms: Haemophilus ducreyi, Haemophilus influenzae, Moraxella catarrhalis, Neisseria gonorrhoeae
• Other microorganisms: Chlamydia pneumoniae, Chlamydia trachomatis, Mycoplasma pneumonia, and Beta-lactamase production should have no effect on azithromycin activity.
• Aerobic and facultative gram-positive microorganisms: Streptococci (Groups C, F, G), Viridans group streptococci
• Aerobic and facultative gram-negative microorganisms: Bordetella pertussis, Legionella pneumophila
• Anaerobic microorganisms: Peptostreptococcus species, Prevotella Livia.

Dosage & Administration

Oral-
Adult:

• 500 mg orally once daily for three days, or 500 mg once on day one, then 250 mg once on days two through five for four days.
• Adults with sexually transmitted diseases caused by Chlamydia trachomatis should receive 1 gm as a single dose, or 500 mg once on day 1, followed by 250 mg once daily for the next two days.

Children:

• 10 mg/kg body weight once daily for 3 days for the child over 6 months
• 200 mg (1 teaspoonful) for 3 days if body weight is 15-25 kg
• 300 mg (1? teaspoonfuls) for 3 days if bodyweight is 26-35 kg; 400 mg (2 teaspoonfuls) for 3 days if bodyweight is 36-45 kg.
• In typhoid fever, 500 mg (2? teaspoonfuls) once daily for 7-10 days is given.

The safety and effectiveness of azithromycin for injection in children or adolescents under 16 years have not been established.

Interaction

The proximity of nourishment and stomach-settling agent decreases azithromycin absorption. Azithromycin should be avoided in patients who are taking ergot alkaloids because of the possibility of ergotism caused by Azithromycin’s interaction with the cytochrome P-450 framework. Because macrolides increase the plasma concentrations of digoxin and cyclosporin, caution should be exercised when co-administration. There is no evidence of a therapeutic relationship between Azithromycin and Warfarin, Theophylline, Carbamazepine, Methylprednisolone, or Cimetidine.

Contraindications

Patients who are hypersensitive to Azyth 250 or any other macrolide antibiotic should avoid taking it. Ergot derivatives and azithromycin should not be taken together. Patients with hepatic disorders should avoid Azyth 250.

Side Effects

Azyth 250 is a well-tolerated antibiotic with few adverse effects. Nausea, vomiting, abdominal discomfort (pain/cramps), flatulence, diarrhea, headache, dizziness, and skin rashes are among the side effects, which are reversible as the medication is stopped.

Pregnancy & Lactation

The pregnancy Category of Azithromycin is B. Creature generation ponders have illustrated that Azithromycin has no proof of hurt to the baby. There are no satisfactory and well-controlled things about pregnant ladies. Since creature generation considers is not continuously prescient of human reaction, Azithromycin ought to be utilized amid pregnancy as it were in the event that satisfactory choices are not accessible. It isn’t known whether Azithromycin is discharged in the breast drain. So, caution ought to be worked out when Azithromycin is managed by nursing ladies.

Precautions & Warnings

• Antacids should not be taken two hours before or after taking Azyth.
• Diarrhea may occur as a side effect, but it should subside once your course is finished. If it does not stop or if you find blood in your stools, contact your doctor.
• If you develop an itchy rash, swelling of the face, throat, or tongue, or breathing difficulties while taking Azyth, stop taking it immediately and notify your doctor.
• Observation for signs of superinfection with non-susceptible organisms, especially fungus, is suggested with any antibiotic. In patients with renal impairment, there is no need to alter the dose.

Storage Conditions

Keep the temperature below 30?C and away from light and moisture. Keep out of children’s reach