Cefaclav 125 (18Pcs Box)

Indications of Cefaclav 150 Tablet

A combination drug called Cefaclav 150 is used to treat various bacterial infections. To stop the growth of the microorganisms and the further spread of the infection, it fights against them. Cefaclav 150 requires a prescription. It’s advised to follow the directions on the prescription.

Pharmacology

A second-generation cephalosporin antibiotic called cefuroxime is bactericidal and kills a variety of Gram-positive and Gram-negative bacteria, including many strains that produce beta-lactamases. Cefuroxime prevents bacteria from producing cell walls by interfering with the transpeptidation process. A naturally occurring beta-lactamase inhibitor, clavulanic acid is created by the bacterium Streptomyces clavuligerus. Its structure is similar to that of beta-lactam antibiotics, and it binds to beta-lactamase enzymes and irreversibly inactivates them. Cefuroxime is a treatment option for bacterial infections because clavulanic acid shields it from degradation by beta-lactamase enzymes.

Cefaclav 150 Tablet Dosage & Administration

Adults (13 years of age and older) and adolescents

• For 5?10 days, take 250 mg b.i.d. for pharyngitis/tonsillitis.
• 250 mg twice daily for 10 days if you have acute bacterial maxillary sinusitis.
• Acute bacterial bronchitis exacerbation: 250?500 mg twice daily for 10 days
• Acute bronchitis secondary bacterial infections: 250?500 mg twice daily for 5?10 days.
• Simple infections of the skin and skin structures: 250?500 mg twice daily for 10 days
• Simple urinary tract infections: Take 250 mg twice daily for 7?10 days.
• Simple Gonorrhea: 1000 mg twice daily Community-acquired pneumonia single dose: 250?500 mg b.i.d. for 5?10 days
• MDR 500 mg b.i.d. for 10?14 days for typhoid fever
  500 mg twice daily for 20 days for early Lyme disease.

Children (3 months to 12 years old)

• 20 mg/kg/day b.i.d. for 5?10 days for pharyngitis/tonsillitis
• 30 mg/kg/day b.i.d. for 10 days if you have acute otitis media
• 30 mg/kg/day b.i.d. for 10 days if you have acute bacterial maxillary sinusitis.
• 10 days of 30 mg/kg/day b.i.d. for impetigo

Interaction

Combining probenecid and cefuroxime-clavulanic acid increases the area under the serum concentration versus the time curve by 50%. Cefuroxime’s bioavailability may be compromised and the effects of postprandial absorption may be counteracted by a medication that reduces stomach acidity.

Contraindications

Cefuroxime-Clavulanic Acid is not recommended for people who have a known cephalosporin allergy or who have Pseudomembranous Colitis.

Cefaclav 150 Tablet Side Effects

• Nausea
• Vomiting
• Diarrhea
• Increased liver enzymes
• Allergic reaction

Pregnancy & Lactation

If at all possible, steer clear of antibiotics during the first trimester. Contrarily, urinary and other infections can be safely treated later in pregnancy with cefuroxime-clavulanic acid. Small amounts of cefuroxime-clavulanic acid are excreted in breast milk. However, it is important to take into account the possibility of the newborn becoming sensitized.

Precautions & Warnings

Cefuroxime should be used with caution in individuals who are taking powerful diuretics and have a history of colitis.

Storage Conditions

Store in a cool, dry place (below 30o C), away from light and moisture. Keep out of the reach of children.