Conasyd 1% Dermal Cream

Tioconazole is used to treat vulvovaginal candidiasis on a local basis (moniliasis). Because Tioconazole has only been found to be beneficial for candidal vulvovaginitis, KOH smears and/or cultures should be used to confirm the diagnosis. Other microorganisms known to cause vulvovaginitis should be screened out using appropriate tests. Studies have shown that women taking oral contraceptives have a cure rate similar to those not taking such agents when treated with Tioconazole.

Pharmacology

Tioconazole binds to 14-demethylase, a cytochrome P-450 enzyme that transforms lanosterol to ergosterol, an important component of yeast membranes. Tioconazole suppresses ergosterol synthesis in this way, leading to an increase in cellular permeability. Tioconazole may also impede endogenous respiration, interact with membrane phospholipids, and prevent yeasts from transforming into mycelial forms and the uptake of purine, impair triglyceride and/or phospholipid biosynthesis, and inhibit the movement of calcium and potassium ions across the cell membrane by blocking the ion transport pathway known as the Gardos channel.

Dosage & Administration

Topical: Apply & massage gently into the affected & surrounding skin area once or twice a day. In intertriginous areas, apply sparingly & smoothed in well to avoid macerating effects. Duration: 1-6 weeks.

Vaginal candidiasis:

Adult: As 6.5% ointment: Admin intravaginally at bedtime as a single dose.

Child: ?12 yr Admin at bedtime as a single dose.

Interactions

Conasyd should not be administered with food. Studies have shown that the bioavailability of isoniazid is reduced significantly when administered with food.

Contraindications

Tioconazole is contraindicated in individuals who have been shown to be sensitive to imidazole antifungal agents or to other components of the ointment

Side-Effects of Conasyd Cream

Occasional local transient & mild irritation; if hypersensitivity reaction develop, treatment should be discontinued & appropriate therapy should be instituted.

Pregnancy & Lactation

Pregnancy Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.