Dermex NN Cream

Indications of Dermex NN  Cream

This medication is recommended for use in the following situations:

• Treatment of refractory eczemas in a short period of time.
• Neurodermatitis.
• Secondary bacterial or fungal infection is present, suspected, or likely in psoriasis (excluding extensive plaque psoriasis).
• Other inflammatory diseases that haven’t responded well to less potent steroids.

Pharmacology of Dermex NN Cream

Clobetasol Propionate is a corticosteroid with a high potency. It’s used to treat severe inflammatory skin conditions including eczema and psoriasis that doesn’t respond to other corticosteroids. Neomycin Sulphate is an aminoglycoside antibiotic that is used to treat bacterial infections. Nystatin is an antifungal that works by interfering with the cell membranes of fungi and yeasts. In general, the mechanism of topical steroids like Clobetasol is unknown. Clobetasol Propionate, on the other hand, is a potent corticosteroid with anti-inflammatory properties. Clobetasol Propionate has a general anti-inflammatory impact on the skin, which is largely attributable to vasoconstriction and a reduction in collagen production. Neomycin suppresses protein synthesis by binding to the ribosomal 30s and 50s subunits of sensitive bacteria. Neomycin also causes a misreading of the mRNA template’s genetic coding, resulting in the incorporation of erroneous amino acids into the developing polypeptide chain. Nystatin works by attaching to sterols in the fungus’ cell membrane, causing a shift in membrane permeability that allows internal components to seep out.

Dosage & Administration of Dermex NN Cream

Adults: Apply sparingly to the affected area once or twice daily until improvement occurs. In very resistant lesions, especially where there is hyperkeratosis, the anti-inflammatory effect of this preparation can be enhanced (if necessary) by occluding the treatment area with polythene. Treatment should not be continued for more than 7 days without medical supervision. If a longer course is necessary, it is recommended that treatment should not be continued for more than 4 weeks without the patient’s condition being reviewed.

Elderly: This preparation is suitable for use in the elderly. Caution should be exercised in cases where a decrease in renal function exists and significant systemic absorption of Neomycin Sulphate may occur.

Children: This preparation is suitable for use in children (2 years and over) at the same dose as adults. A possibility of increased absorption exists in very young children, thus this cream/ointment is not recommended for use in neonates and infants (younger than 2 years).

Interaction of Dermex NN Cream

Following considerable systemic absorption, neomycin sulfate can enhance and extend the respiratory depressive effects of neuromuscular blocking drugs. Systemic exposure to Neomycin Sulphate is predicted to be limited if administered according to the instructions, and medication interactions are unlikely to be substantial. There have been no reports of dangerous interactions with Clobetasol Propionate or Nystatin.

Contraindications

Rosacea, acne vulgaris, and perioral dermatitis, as well as primary cutaneous viral infection (e.g., Herpes simplex, chicken pox) and hypersensitivity to the preparation, are all contraindications.

Side Effects of Dermex NN  Cream

Long-term use of a significant quantity or treatment of a broad region, like with other topical corticosteroids, can result in enough systemic absorption to cause hypercortisolism. If occlusive dressings are applied, the impact is more likely to occur in babies and children. Local atrophic changes in the skin, such as thinning, striae, and dilatation of the superficial blood vessels, can occur after prolonged and intense therapy with highly active corticosteroid formulations, especially when occlusive dressings are employed or when skin folds are implicated. Topical steroids have been linked to pigmentation alterations and hypertrichosis.

Pregnancy & Lactation

There is minimal evidence to support the use of topically administered Neomycin during pregnancy and breastfeeding. However, because neomycin in the maternal blood might pass the placenta and provide a potential risk of fetal harm, the preparation should not be used during pregnancy or breastfeeding. Clobetasol Propionate’s safety in nursing women has not been verified.

Precautions & Warnings

Adrenal suppression can occur even without blockage, thus long-term continuous topical treatment should be avoided wherever feasible, especially in babies and children. If the preparation is applied to the eyelids, it must be carefully monitored to ensure that it does not enter the eye, since this might cause glaucoma. If the medicine gets into the eye, the afflicted eye should be rinsed out completely with plenty of water.

Storage Conditions

Keep the temperature below 25?C. Do not allow yourself to get frozen. Keep out of children’s reach.