Esonix – IV 20 Injection

Indications of Esonix – IV 20

Heartburn, Acid Related Dyspepsia, Peptic Ulcer Disease, Zollinger-Ellison Syndrome, Gastroesophageal Reflux Disease (GERD), Helicobacter pylori infection, Erosive Esophagitis, and Gouty Arthritis are among the conditions that esomeprazole is prescribed to treat.

Pharmacology

Esomeprazole (Esonix) is a proton pump inhibitor that inhibits gastric acid secretion by inhibiting the H+/K+ATPase in the gastric parietal cell specifically. Esonix reduces gastric acidity by blocking the final step in acid production by acting specifically on the proton pump.

Dosage & Administration

Dosage:
Gastroesophageal Reflux Disease (GERD)
Healing of Erosive Esophagitis: 20 mg or 40 mg Once Daily for 4 to 8 Weeks*
Maintenance of Healing of Erosive Esophagitis: 20 mg Once Daily
Symptomatic Gastroesophageal Reflux Disease: 20 mg Once Daily for 4 Weeks**
Pediatric GERD:
a) 12 to 17-Year-Olds: Short-term Treatment of GERD 20 mg or 40 mg Once Daily for up to 8 Weeks
b) 1 to 11 Year Old’s+: Short-term Treatment of Symptomatic GERD 10 mg Once Daily for up to 8 Weeks
Healing of Erosive Esophagitis:
a) weight <20 kg 10 mg Once Daily for 8 Weeks
b) weight ?20 kg 10 mg or 20 mg Once Daily for 8 Weeks
Risk Reduction of NSAID-Associated Gastric Ulcer: 20 mg or 40 mg Once Daily for up to 6 months
H. pylori eradication to reduce the risk of Duodenal Ulcer recurrence:
Triple Therapy:
i) Esomeprazole 40 mg Once Daily for 10 Days
ii) Amoxicillin 1000 mg Twice Daily for 10 Days
iii) Clarithromycin 500 mg Twice Daily for 10 Days
Pathological Hypersecretory Conditions Including Zollinger-Ellison Syndrome: 40 mg Twice Daily
Injection
GERD with Erosive Esophagitis:
Adults: Dose is either 20 mg or 40 mg Esomeprazole given once daily by intravenous injection (not less than 3 minutes) or intravenous infusion (10
minutes to 30 minutes).
Pediatric: Give the following doses once daily as an intravenous infusion over 10 minutes to 30 minutes.
1 year to 17 years:
Body weight less than 55 kg: 10 mg
Body weight 55 kg or greater: 20 mg
1 month to less than 1 year of age: 0.5 mg/kg
Dosage & Administration
Gastroesophageal Reflux Disease (GERD)
Healing of Erosive Esophagitis: 20 mg or 40 mg Once Daily for 4 to 8 Weeks*
Maintenance of Healing of Erosive Esophagitis: 20 mg Once Daily
Symptomatic Gastroesophageal Reflux Disease: 20 mg Once Daily for 4 Weeks**
Pediatric GERD:
a) 12 to 17-Year-Olds: Short-term Treatment of GERD 20 mg or 40 mg Once Daily for up to 8 Weeks
b) 1 to 11 Year Old’s+: Short-term Treatment of Symptomatic GERD 10 mg Once Daily for up to 8 Weeks
Healing of Erosive Esophagitis:
a) weight <20 kg 10 mg Once Daily for 8 Weeks
b) weight ?20 kg 10 mg or 20 mg Once Daily for 8 Weeks
Risk Reduction of NSAID-Associated Gastric Ulcer: 20 mg or 40 mg Once Daily for up to 6 months
H. pylori eradication to reduce the risk of Duodenal Ulcer recurrence:
Triple Therapy:
i) Esomeprazole 40 mg Once Daily for 10 Days
ii) Amoxicillin 1000 mg Twice Daily for 10 Days
iii) Clarithromycin 500 mg Twice Daily for 10 Days
Pathological Hypersecretory Conditions Including Zollinger-Ellison Syndrome: 40 mg Twice Daily
Injection
GERD with Erosive Esophagitis:
Adults: Dose is either 20 mg or 40 mg Esomeprazole given once daily by intravenous injection (not less than 3 minutes) or intravenous infusion (10
minutes to 30 minutes).
Pediatric: Give the following doses once daily as an intravenous infusion over 10 minutes to 30 minutes.
1 year to 17 years:
Body weight less than 55 kg: 10 mg
Body weight 55 kg or greater: 20 mg
1 month to less than 1 year of age: 0.5 mg/kg
Dosage & Administration
Gastroesophageal Reflux Disease (GERD)
Healing of Erosive Esophagitis: 20 mg or 40 mg Once Daily for 4 to 8 Weeks*
Maintenance of Healing of Erosive Esophagitis: 20 mg Once Daily
Symptomatic Gastroesophageal Reflux Disease: 20 mg Once Daily for 4 Weeks**
Pediatric GERD:
a) 12 to 17-Year-Olds: Short-term Treatment of GERD 20 mg or 40 mg Once Daily for up to 8 Weeks
b) 1 to 11 Year Old’s+: Short-term Treatment of Symptomatic GERD 10 mg Once Daily for up to 8 Weeks
Healing of Erosive Esophagitis:
a) weight <20 kg 10 mg Once Daily for 8 Weeks
b) weight ?20 kg 10 mg or 20 mg Once Daily for 8 Weeks
Risk Reduction of NSAID-Associated Gastric Ulcer: 20 mg or 40 mg Once Daily for up to 6 months
H. pylori eradication to reduce the risk of Duodenal Ulcer recurrence:
Triple Therapy:
i) Esomeprazole 40 mg Once Daily for 10 Days
ii) Amoxicillin 1000 mg Twice Daily for 10 Days
iii) Clarithromycin 500 mg Twice Daily for 10 Days
Pathological Hypersecretory Conditions Including Zollinger-Ellison Syndrome: 40 mg Twice Daily
Injection
GERD with Erosive Esophagitis:
Adults: Dose is either 20 mg or 40 mg Esomeprazole given once daily by intravenous injection (not less than 3 minutes) or intravenous infusion (10
minutes to 30 minutes).
Pediatric: Give the following doses once daily as an intravenous infusion over 10 minutes to 30 minutes.
1 year to 17 years:
Body weight less than 55 kg: 10 mg
Body weight 55 kg or greater: 20 mg
1 month to less than 1 year of age: 0.5 mg/kg

Administration:

Esomeprazole tablet or capsule: should be swallowed whole and taken one hour before a meal.

Interaction of Esonix – IV 20

By CYP2C19 and CYP3A4, esomeprazole is extensively metabolized in the liver. Esomeprazole is not likely to inhibit the CYPs 1A2, 2A6, 2C9, 2D6, or 3A4, according to in vitro and in vivo research. There shouldn’t be any clinically significant interactions between medications and those processed by these CYP enzymes. According to drug interaction studies, there are no clinically significant interactions between esomeprazole and phenytoin, warfarin, quinidine, clarithromycin, or amoxicillin.

Contraindications

Patients with known hypersensitivity to any of the formulations should not take esomeprazole.

Side Effects of Esonix – IV 20

The side effects of Esomeprazole that are most frequently mentioned are headache, diarrhea, nausea, flatulence, abdominal pain, constipation, and dry mouth. When compared to short-term treatment, relevant side events occurring after maintenance therapy up to 12 months do not differ in type.

Pregnancy & Lactation

There are no adequate and well-controlled studies on pregnant women. Animal studies have revealed no teratogenic effects. The excretion of esomeprazole in milk has not been studied. Breastfeeding should therefore be discontinued if the use of esomeprazole is considered essential.

Precautions & Warnings

General: The occurrence of stomach cancer is not ruled out by symptomatic response to esomeprazole medication.

Patients should take esomeprazole capsules at least an hour before meals, according to the information. One spoonful of applesauce can be put into an empty bowl, the Esomeprazole capsules can be opened, and the pellets inside the capsule can be carefully dumped onto the applesauce for patients who have trouble swallowing capsules. After combining the pellets and applesauce, immediately ingest the mixture. Use only cold applesauce that is soft enough to be taken without chewing. You shouldn’t chew or shatter the pellets. It is not advised to keep the pellet/applesauce mixture for later usage. Esomeprazole can be taken with antacids.

Storage Conditions

Store at a temperature not exceeding 30?C in a dry place. Protect from light and moisture. Keep out of reach of children.