Description:
Indications
For the treatment of mild to moderately severe bacterial infections caused by penicillin-susceptible pathogens that respond to oral penicillin therapy, such as tonsillitis, pharyngitis, laryngitis, otitis media, and sinusitis, as well as infections of the ear, nose, and throat.
Bronchitis, pneumonia, and bronchopneumonia are infections of the lower respiratory tract.
Pharmacology
Penicillin V (phenoxymethyl penicillin) is an acid-stable antibiotic that is absorbed from the upper part of the small intestine. The potassium salt of Phenoxymethyl penicillin is the most absorbable of the various forms of Phenoxymethyl penicillin. This can be taken with or without food, but the best absorption occurs when the drug is taken orally at least 1 hour before or 2 hours after the meal.
Administration & Dosage
It is best to take phenoxymethyl penicillin on an empty stomach, preferably one hour before meals. The tablets are swallowed whole, without chewing, with plenty of liquid. The bottle must be vigorously shaken before each use of this syrup.
Adults: 250-500 mg six times a day
Children over the age of one year: 125-250 mg 1-2 teaspoonful of 125 mg/5 ml powder for suspension every 6 hours (5-10 ml) 12-1 teaspoonful 250 mg/5 ml powder for suspension every 6 hours (2.5-5 ml) 6 hourly intervals.
Interaction
The rate of absorption is reduced when food is consumed at the same time. To achieve the highest possible rate of absorption, Phenoxymethyl penicillin should be taken on an empty stomach, preferably one hour before meals.
Contraindications
Patients who are hypersensitive to penicillins or any of the excipients should not be given phenoxymethyl Penicillin. Patients with severe gastrointestinal disorders, including vomiting and diarrhea, should not be treated with phenoxymethyl penicillin.
Side Effect
Hypersensitivity reactions involving the skin (e.g. urticaria, morbilliform or scarlatiniform rashes, pruritus), eosinophilia, or more serious allergic reactions, such as drug fever, vasculitis, serum sickness, or interstitial nephritis, can occur on rare occasions. Angioneurotic oedema, laryngeal oedema, bronchial spasm, and shock may accompany anaphylactic or anaphylactoid reactions.
Pregnancy & Lactation
The antibiotic phenoxymethylpenicillin passes through the placenta. This can be used at any point during pregnancy if the conditions are met. In small amounts, phenoxymethylpenicillin passes into breast milk. This can be used during lactation, but the infant may experience diarrhoea and yeast colonization of the mucous membranes.
Precautions & Warnings
It’s important to consider the possibility of cross-allergy between cephalosporins and penicillins. The potassium content of Phenoxymethyl Penicillin may need to be considered when treating patients with heart disease or serious electrolyte disturbances from other causes. Beta-lactams put the patient at risk for encephalopathy (which can cause convulsions, confusion, and loss of consciousness).
Storage Conditions
Keep the temperature below 30?C and away from light and moisture. Keep out of children’s reach.
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