Rolac 10mg 14pcs

Description:

Rolac 10 is used to treat moderate to severe acute postoperative pain in the short term.PharmacologyThe non-steroidal anti-inflammatory medication ketorolac tromethamine is a powerful painkiller (NSAIDs). It works by preventing prostaglandin production by inhibiting the cyclooxygenase enzyme system. At its analgesic dosage, it has a little anti-inflammatory action.Dosage & AdministrationTablet-The recommended dose is Rolac 10 mg every 4-6 hours. It should be used short-term only (up to 7 days) and is not recommended for chronic use. Doses exceeding 40 mg/day are not recommended.
Injection-Ketorolac injection may be used as a single or multiple dose, on a regular or when the necessary schedule for the management of moderately severe, acute pain that requires analgesia at the opioid level, usually in a postoperative setting. When administering Ketorolac injection, the IV bolus must be given over no less than 15 seconds. The IM administration should be given slowly and deeply into the muscle. The analgesic effect begins within 30 minutes with maximum effect in 1 to 2 hours after dosing IV or IM. Duration of analgesic effect is usually 4 to 6 hours.

Single-Dose Treatment-IM Dosing (Adult):

Patients <65 years of age: One dose of 60 mg.Patients >65 years of age, really impaired and/or less than 50 kg of body weight: One dose of 30 mg.IV Dosing (Adult):Patients <65 years of age: One dose of 30 mg.Patients >65 years of age, really impaired and/or less than 50 kg of body weight: One dose of 15 mg.IV or IM Dosing (2 to 16 years of age):IM Dosing: One dose of 1 mg/kg up to a maximum of 30 mg.IV Dosing: One dose of 0.5 mg/kg up to a maximum of 15 mg.Multiple-Dose Treatment (IV or IM)-Patients <65 years of age: The recommended dose is 30 mg Ketorolac injection every 6 hours. The maximum daily dose should not exceed 120 mg. Patients >65 years of age, really impaired patients, and patients less than 50 kg: The recommended dose is 15 mg Ketorolac injection every 6 hours. The maximum daily dose for these populations should not exceed 60 mg. For breakthrough pain, do not increase the dose or the frequency of Ketorolac Tromethamine.Conversion from Parenteral to Oral Therapy: Ketorolac tablets may be used either as monotherapy or as follow-on therapy to parenteral Ketorolac. When Ketorolac tablets are used as a follow-on therapy to parenteral Ketorolac, the total combined daily dose of ketorolac (oral + parenteral) should not exceed 120 mg in younger adults patients or 60 mg in elderly patients on the day the change of formulation is made. On subsequent days, oral dosing should not exceed the recommended daily maximum of 40 mg. Ketorolac IM should be replaced by Ketorolac tablet as soon as feasible. The total duration of combined parenteral and oral treatment should not exceed 5 days.InteractionRolac 10’s negative effects are exacerbated by other NSAIDs or aspirin.Anticoagulants: Increase the effectiveness of anticoagulants.Reduce the antihypertensive impact of beta-blockers.Angiotensin-converting enzyme inhibitors (ACE inhibitors) raise the risk of renal impairment.Methotrexate: Increase methotrexate toxicity.ContraindicationsPatients who are hypersensitive to ketorolac or other NSAIDs should avoid using it. It should not be given to youngsters under the age of sixteen. It’s also not a good idea to use it as a pre-surgery analgesic.Side EffectsCommonly occurring side effects are nausea, vomiting, gastrointestinal bleeding, melena, peptic ulcer, pancreatitis, anxiety, drowsiness, headache, excessive thirst, fatigue, bradycardia, hypertension, palpitation, chest pain, infertility in females and pulmonary edema.Pregnancy & LactationUS FDA Pregnancy category of Rolac 10 is C. So, Ketorolac Tromethamine should be avoided in pregnancy and lactation unless the potential benefits to the other outweigh the possible risks to the fetus.Precautions & WarningsCaution should be exercised in patients over the age of 65 years. Caution should also be taken in patients with active or suspected peptic ulcer or gastrointestinal bleeding or asthma and liver dysfunction.Therapeutic ClassDrugs used for Rheumatoid Arthritis, Non-Opioid AnalgesicsStorage ConditionsKeep in a dry place away from light and heat. Keep out of the reach of children.