Trispray Nasal Spray

Acute lupus erythematosus, Allergic and inflammatory disorders, Allergic dermatitis, Allergic rhinitis, Allergies, Anogenital pruritus, Apthous ulcer, Asthma, Asthma prophylaxis, Atopic eczema, Diabetic macular edema, Hair loss, Hay fever, Inflammatory joint disease, Inflammatory skin disorders, Insect stings, Joint stiffness, Mouth ulcers, Stings, Vitiligo.

Dosage: Intra-articular-

Inflammatory joint diseases:

• Adult: As acetonide: Smaller joints: 2.5-5 mg (up to 10 mg), larger joints: 5-15 mg (up to 40 mg). Max: 20-80 mg/treatment. As hexacetonide: Initial: 2-20 mg/day.

Intradermal-
Inflammatory skin conditions:

• Adult: As acetonide: 1-3 mg/site. Max: 30 mg in total if several sites of inj used. As diacetate: 5 mg in divided doses for small lesions or up to 48 mg in divided doses for large lesions. Max: 12.5 mg/inj site. Max: 25 mg/lesion. As hexacetonide: max 500 mcg per square inch or 80 mcg/cm2 of affected skin.

Intramuscular-
Symptomatic control for hay fever:

• Adult: As acetonide: 40-100 mg via deep IM into gluteal muscles. As diacetate: 40 mg wkly.
• Child: As acetonide: deep IM into gluteal muscle: initial 0.11 to 1.6 mg/kg/day in 3-4 divided doses. Do not use in premature infants and infants of low birth weight as it contains benzyl alcohol.

Intramuscular-
Suppression of allergic and inflammatory disorders:

• Adult: As acetonide: 20-80 mg via deep IM into gluteal muscles. As diacetate: 40 mg inj.
• Child: As acetonide: deep IM into gluteal muscle: initial 0.11 to 1.6 mg/kg/day in 3-4 divided doses. Do not use in premature infants and infants of low birth weight as it contains benzyl alcohol.

Mouth/Throat-
Mouth ulceration:

• Adult: A small amount (about 0.6 cm) of the 0.1% paste is pressed onto the lesion without rubbing until a thin film develops. Apply 2 or 3 times daily, preferably after meals. Re-evaluate if recovery does not occur after 7 days of treatment.

Nasal-
Treatment and prophylaxis of allergic rhinitis:

• Adult: As acetonide: Initially, 2 sprays (110 mcg) into each nostril once daily, reduced to 1 spray (55 mcg) when under control.
• Child: 6-12 yr: as acetonide: 1 spray (55 mcg) into each nostril once daily. Increased to 220 mcg daily in severe cases.

Oral-
Allergic and inflammatory disorders:

• Adult: 4-48 mg daily.

Topical/Cutaneous-
Inflammatory skin conditions:

• Adult: As acetonide: Apply a 0.025-0.5% cream/lotion/ointment sparingly onto affected area 2-3 times daily. Lower concentrations may be used up to 4 times daily.

Side effects: HPA axis supression, intracranial hypertension, Cushing’s syndrome, growth retardation in children; osteoporosis, fractures. Peptic ulceration; glaucoma; hyperglycaemia; GI upsets; increased appetite; increased fragility of skin; behavioural changes. Topical: Systemic absorption if applied to large areas, broken skin or under occlusive dressing.