Xten 20mg Tablet 10Pcs

Description:

IndicationsTenoxicam is indicated for the symptomatic treatment of the following painful inflammatory and degenerative disorders of the musculoskeletal system:Rheumatoid arthritis.Osteoarthritis.Arthrosis.Ankylosing spondylitis.Extra-articular disorders, e.g. tendinitis, bursitis, periarthritis of the shoulders (shoulder-hand syndrome) or hips, strains, and sprains.Acute gout. PharmacologyTenoxicam is an anti-inflammatory, analgesic, and antipyretic non-steroidal anti-inflammatory medication (NSAID) that also inhibits platelet aggregation. Prostaglandin biosynthesis is inhibited by tenoxicam. Tenoxicam may operate as a scavenger for active oxygen at the site of inflammation, according to in vitro testing of leukocyte peroxidase. Tenoxicam inhibits human metalloproteinases (stromelysin and collagenase), which cause cartilage disintegration, in vitro. Tenoxicam’s therapeutic effectiveness in the treatment of painful inflammatory and degenerative musculoskeletal illnesses can be attributed to these pharmacological actions, at least in part. Tenoxicam was not found to be mutagenic.               Dosage & AdministrationStandard dosage: For all indications except acute gout, a daily dosage of 20 mg should be given at the same time of day.

In acute attacks of gout: The recommended dose for acute attacks of gout is 40 mg once daily for two days followed by 20 mg once daily for a further five days.

In the treatment of chronic disorders: The therapeutic effect of tenoxicam is evident early in treatment but there is a progressive increase in response over time. In chronic disorders, daily doses higher than 20 mg should be avoided since this would increase the frequency and intensity of unwanted reactions without significantly increasing efficacy. For patients needing long-term treatment, a reduction to a daily oral dose of 10 mg may be tried for maintenance.

Special dosage instructions: In principle, the above dosage recommendations also apply to elderly patients and to patients suffering from kidney or liver disease. Because of lack of clinical experience, no dosage recommendations have so far been established for children and adolescents.The tablets should be taken with a glass of water. It is preferable to take this medicine during or immediately after a meal. InteractionSalicylate, like other NSAIDs, displaces tenoxicam from protein-binding sites, increasing tenoxicam clearance and volume of distribution. Because of the increased risk of gastrointestinal side effects, concurrent therapy with salicylate or other NSAIDs should be avoided. Some NSAIDs and methotrexate co-administration has been linked to lower methotrexate renal tubular secretion, increased methotrexate plasma concentrations, and severe methotrexate toxicity. As a result, when Tenoxicam is used with methotrexate, vigilance should be exercised. In the modest number of patients who received concomitant therapy, no clinically meaningful interaction was discovered. ContraindicationsTenoxicam should not be given to patients because:known to have a high sensitivity to the medication;who have symptoms of asthma, rhinitis, or urticaria after using salicylates or other non-steroidal anti-inflammatory medicines (NSAIDs);Gastritis, gastric and duodenal ulcers are all diseases of the upper gastrointestinal tract that people suffer from or have suffered from. Side EffectsTenoxicam was found to be well tolerated in the indicated dose in clinical trials involving large numbers of individuals. In most cases, the negative effects were minor and only lasted a short time. Treatment has to be interrupted in a limited number of patients due to unfavorable side effects. Tenoxicam taken parenterally has a good local tolerance. The following are some of the side effects that have been reported:The frequency is larger than 1%.- Gastrointestinal tract discomfort, including gastric, epigastric, and abdominal pain, dyspepsia, heartburn, and nausea.Dizziness and headaches are symptoms of the central nervous system.The frequency is less than 1%.- Constipation, diarrhea, stomatitis, gastritis, vomiting, ulcers, etc. – Gastrointestinal tract: constipation, diarrhea, stomatitis, gastritis, vomiting, ulcers, etc. Pregnancy & LactationNSAIDs suppress prostaglandin synthesis, and when taken late in pregnancy, they can cause the fetal ductus arteriosus to close, prolong labor, and delay parturition. Treatment should be avoided during the third trimester of pregnancy. Tenoxicam enters into breast milk in a very modest level (about 0.2 percent) based on data from single-dose administration. There have been no reports of harmful effects in breast-fed infants whose mothers are using Tenoxicam. However, infants should be weaned or the medicine should be stopped. Precautions & WarningsNSAIDs suppress prostaglandin synthesis, and when taken late in pregnancy, they can cause the fetal ductus arteriosus to close, prolong labor, and delay parturition. Treatment should be avoided during the third trimester of pregnancy. Tenoxicam enters into breast milk in a very modest level (about 0.2 percent) based on data from single-dose administration. There have been no reports of harmful effects in breast-fed infants whose mothers are using Tenoxicam. However, infants should be weaned or the medicine should be stopped.Storage ConditionsProtect from light and moisture by storing in a cool, dry place below 25°C. Keep out of children’s reach.